%0 Journal Article
%T Biosynthesis-Based Metabolic Engineering and Combinatorial Biosynthesis<br>以生物合成为基础的代谢工程和组合生物合成
%A LIU Wen TANG Gong-li
%A <br>刘文
%A 唐功利
%J 中国生物工程杂志
%D 2005
%I 
%X Metabolic engineering and combinatorial biosynthesis are becoming the focus of intense research activity of drug discovery and development in the fields of biology, chemistry, and medical sciences. Based on the unusual molecular architecture and phenomenal biological activities of natural products, particularly polyketides and polypeptides, elucidation of their biosynthetic machineries will lay on the foundation of novel analogs generation by rational engineering of their biosynthetic pathways, and eventually facilitate the application of biological and chemical technology to meet the challenge of drug discovery and development in microorganisms.
%K Biosynthesis Metabolic engineering Combinatorial biosynthesis<br>生物合成
%K 代谢工程
%K 组合生物合成
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=C787B8F3060C7B0A&yid=2DD7160C83D0ACED&vid=C5154311167311FE&iid=CA4FD0336C81A37A&sid=CA4FD0336C81A37A&eid=94C357A881DFC066&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=8&reference_num=30