%0 Journal Article
%T Research Progress in Accessory Gene Regulatory System of Staphylococcus aureus<br>金黄色葡萄球菌附属基因调节系统研究进展
%A WANG Jun-hua
%A QUAN Chun-shan
%A ZHENG Wei
%A Li Wei
%A FAN Sheng-di
%A <br>王军华
%A 权春善
%A 郑维
%A 李巍
%A 范圣第
%J 中国生物工程杂志
%D 2008
%I 
%X Staphylococcus aureus is a primary pathogen that poses a serious health threat as a consequence of multiantibiotic resistance. S. aureus can cause diverse serious diseases in humans and animals through the production of toxins, most toxin genes are positively controlled by the accessory gene regulator (agr) system which is responsible for the regulation of more than 30 virulence factors in S. aureus. The agr system which could be a useful target for drug selection is one of the most extensively studied quorum sensing systems for its potential relevance to human disease. Yet many questions regarding the agr signaling remain unsolved. Herein, we review the agr system as we currently understand them and discuss the inconsistencies of the role and fundamental mechanisms of agr in staphylococcal infections.
%K Staphylococcus aureus
%K agr
%K quorum sensing
%K virulence
%K resistant<br>金黄色葡萄球菌
%K agr
%K 群体感应
%K 毒力
%K 抗药性
%K 黄色葡萄球菌
%K 附属
%K 基因调节
%K 调节系统
%K Staphylococcus
%K aureus
%K System
%K Gene
%K Progress
%K 价值
%K 潜在应用
%K 问题
%K 发现
%K 过程
%K 现状
%K 感应系统
%K 群体感应
%K 模型
%K 抑制机制
%K 激活
%K 研究
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=F96909FF52F72368A677532156637E1A&yid=67289AFF6305E306&vid=D3E34374A0D77D7F&iid=B31275AF3241DB2D&sid=39EEF47180459690&eid=A4FA325EA800C820&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=30