%0 Journal Article
%T The Development of Liposomes of Peptides and Protein Drugs<br>多肽、蛋白类药物脂质体的研究进展
%A ZHANG Hong-bo
%A XIANG Qi
%A ZHAO Wen
%A HUANG Ya-dong
%A LI Xiao-kun
%A <br>张宏波
%A 项琪
%A 赵文
%A 黄亚东
%A 李校堃
%J 中国生物工程杂志
%D 2007
%I 
%X Liposomes are artificial membrane vesicles which can be used as either passive or active targeted drug carrier systems. In polypeptide and protein drug- delivery systems, liposomes have some unique therapeutic advantages, such as the ability to deliver drugs to specific sites, to protect polypeptide and protein from degradation in the digestion track , and to increase the systemic circulation time of the drug when PEGylated liposomes are used. In this article, the latest developments including the novel methods of liposomal preparation, new forms of liposomes and the progress in industrialized production of liposomes, are summarized. In addition, some problems existing in this drug-delivery system are put forward and some possible developments of polypeptide and protein liposomes in the future is prospected. Although liposomes have been made much progress in biological area, there still exist many tough problems having not been settled.
%K Polypeptide Protein Drug Liposome<br>多肽
%K 蛋白质
%K 药物
%K 脂质体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=C7D8824FFDB9247F&yid=A732AF04DDA03BB3&vid=DB817633AA4F79B9&iid=B31275AF3241DB2D&sid=74011071555EB4E5&eid=F24949CFDB502409&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=26