%0 Journal Article
%T Natural Anti-infectious Molecule: Bactericidal/ permeability- increasing Protein<br>天然抗感染分子-细菌透性增加蛋白
%A MA Hai-rong
%A SUN Yi
%A CAO Xu
%A WANG Han-qing
%A <br>马海蓉
%A 孙仪
%A 曹旭
%A 汪汉卿
%J 中国生物工程杂志
%D 2006
%I 
%X Endotoxins are lipopolysaccharides ( LPS) , major component of out wall in Gram-negative bacteria. Often they are considered as "prime criminals" of triggering systemic inflaming reaction such as sepsis, bacteremia and so on. It was found in recent years that bactericidal/permeability-increasing protein, a 55kDa member of lipid-related protein family, was a kind of natural molecule of anti-infection and it has special endotoxin-neutralising activity and antibacterial activity. Comprehensive phase II/III clinical trials demonstrated the feasibility and safety of recombinant BPI. So pharmaceutical corporations are attracted to try to apply it to therapy.
%K Bactericidal/permeability-increasing protein Endotoxin Immunity Sepsis Lipopolysaccharide<br>细菌透性增加蛋
%K 白内毒
%K 素免
%K 疫脓毒症
%K 脂多糖
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=AF25675BC7895B8B&yid=37904DC365DD7266&vid=96C778EE049EE47D&iid=DF92D298D3FF1E6E&sid=BB0EA31DB1B01173&eid=10F298ED9F164662&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=26