%0 Journal Article
%T Advances in methodology for aptamer selection<br>适配子筛选技术进展
%A ZHANG Hui-qing
%A FANG Nian
%A ZHANG Kun-he
%A <br>张慧卿
%A 方念
%A 张焜和
%J 中国生物工程杂志
%D 2008
%I 
%X The methods for aptamer selection have been modified and developed in recent years. Selection efficiency has been increased due to the improvement in separation of bound and unbound nucleic acids; applicability of aptamers has been improved due to the development of primer-free SELEX and the utilization of short oligonucleotide library; more research requirements have been satisfied due to the functional modifications of aptamer selection methods. All the methodological advances enhance the potential value of aptamers in basic researches and clinical applications.
%K Apatmer
%K SELEX
%K Methodology<br>适配子
%K SELEX技术
%K 适配子
%K 筛选技术
%K Selection
%K Aptamer
%K 价值
%K 临床应用
%K 方法
%K 研究
%K 功能
%K 范围
%K 寡核苷酸文库
%K 结合部位
%K 效率
%K 分离技术
%K 游离核酸
%K 发展
%K 改良
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=E5A26BA31C37990933F80EBFA20AC38F&yid=67289AFF6305E306&vid=D3E34374A0D77D7F&iid=CA4FD0336C81A37A&sid=A63576421B012172&eid=7F5DDA4924737DF5&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=31