%0 Journal Article
%T Capsid-targeted viral inactivation: a new antiviral strategy<br>衣壳蛋白靶向灭活 一种新型抗病毒策略
%A WANG Zhong-hua
%A QIU Hua-ji
%A CHEN Wei-duo
%A <br>王忠华
%A 仇华吉
%A 陈维多
%J 中国生物工程杂志
%D 2007
%I 
%X Capsid-targeted viral inactivation (CTVI) is a new antiviral strategy, in which nucleases fused to viral coat proteins are expressed in infected cells and become incorporated during virion assembly, and degrade viral nucleic acids. The nucleases commonly used in CTVI are SN nuclease from Staphylococcus, Barnase from Bacillus amyloliquefaciens and RNase HI from E. coli. CTVI has successful applications in HIV-1 hepatitis B virus, murine leukaemia virus, Dengue virus, etc.The principle, advantages, applications and prospect of CTVI were mainly described.
%K Capsid-targeted viral inactivation (CTVI) Capsid-nuclease fusion protein Antiviral strategy<br>衣壳蛋白靶向灭活(CTVI)
%K 衣壳蛋白-核酸酶融合蛋白
%K 抗病毒策略
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=BEB68168F0EB6E63&yid=A732AF04DDA03BB3&vid=DB817633AA4F79B9&iid=38B194292C032A66&sid=7E8E8B150580E4AB&eid=08805F9252973BA4&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=0&reference_num=36