%0 Journal Article
%T Phosphorylation Reaction between 4-Aminoantiprine and Di-isopropyl Phosphite Studied by NMR and ESI-MS/MS<br>一种新的4-氨基安替比林磷酰化产物的结构确定
%A CHEN Xiao-lan
%A WU Jian-li
%A LU Jian-sha
%A QU Ling-Bo
%A ZHAO Yu-fen
%A <br>陈晓岚
%A 吴建丽
%A 卢建莎
%A 屈凌波
%A 赵玉芬
%J 波谱学杂志
%D 2005
%I 
%X The Atheron-Todd reaction has been used extensively for synthesis of phosphates and phosphoroamidates. In this study, we show that 4-aminoantipyrine can be phosphorylated by a modified Atheron-Todd procedure in which diisopropyl phosphite (DIPPH) and tetrachloromethane mixture was dropped into a solution mixture of 4-aminoantipyrine, trithylamine and dioxane. The reaction product N-DIPP-4-antiprine was obtained with good yield, its structure was elucidated by NMR, ESI-MS and X-ray crystallography.
%K NMR<br>ESI-MS
%K 二异丙基亚磷酸酯(DIPPH)
%K 磷酰化
%K 4-氨基安替比林
%K N-DIPP-4-氨基安替比林
%K X-ray晶体衍射
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=1A3C8C6E452BD1AF5A6B6B99BA3989C9&aid=ED8DE7ED0782C531&yid=2DD7160C83D0ACED&vid=BC12EA701C895178&iid=0B39A22176CE99FB&sid=79D2EF35F60110C2&eid=1B64850025D0BBBE&journal_id=1000-4556&journal_name=波谱学杂志&referenced_num=0&reference_num=8