%0 Journal Article
%T Pure and Mixed Enantiomer of Moxifloxacin Hydrochloride Studied by NMR Spectroscopy<br>盐酸莫西沙星对映体及混合体的核磁共振研究
%A YANG Qiu-qing
%A LIU Bo-qian
%A HAN Kang
%A <br>杨秋青
%A 刘博谦
%A 韩康
%J 波谱学杂志
%D 2012
%I 
%X The structures of pure and mixed enantiomer of moxifloxacin hydrochloride were elucidated by NMR.The chemical shift of the spectral peaks were assigned using 1H-and 13C NMR,COSY,HSQC,HMBC and 2D NOESY techniques,as well as 19F-13C coupled splitting.It was found that 19F-13C coupling exists not only in the six-membered ring,but also in the five-membered heterocyclic ring,and that 4JFC in the five-membered heterocyclic ring is larger than 3JFC and 4JFC in the six-membered ring.The spectral characteristics of the pure and mixed enantiomer of moxifloxacin hydrochloride were summarized.A method was proposed to differentiate the pure and mixed enantiomer of moxifloxacin hydrochloride.
%K NMR
%K 
%K moxifloxacin hydrochloride
%K enantiomer
%K identification method<br>核磁共振(NMR)
%K 盐酸莫西沙星
%K 对映体
%K 区别方法
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=1A3C8C6E452BD1AF5A6B6B99BA3989C9&aid=B39D47F72CB13A768E9BE0F7C4E1CB21&yid=99E9153A83D4CB11&vid=771469D9D58C34FF&iid=CA4FD0336C81A37A&sid=EFD65B51496FB200&eid=B344543C2864D684&journal_id=1000-4556&journal_name=波谱学杂志&referenced_num=0&reference_num=0