%0 Journal Article
%T Effect of STZ-induced diabetes on bone mineral density and testosterone<br>STZ诱导的糖尿病对骨密度和血清睾酮的影响（英文）
%A FEI Yu-Rong
%A WEI Dan
%A LI Ming
%A ZHANG Min
%A ZHANG Xiao-Lin
%A DING Wen-Jun
%A YANG Jian-Hong
%A <br>费聿荣 韦
%A 单 李
%A 明 张
%A 敏 张晓琳 丁文军 杨建虹
%J 中国科学院研究生院学报
%D 2007
%I 
%X Toinvestigate the effect of diabetes mellitus on bone metabolism,bone mineral density(BMD) and serumtestosterone were studied in STZ-induced diabetic male rats.Male Wistar rats were randomly divided into control group(n=6),diabetic group(n=5) and insulin-treated diabetic group(n=5).Diabetes was intravenously induced by injection of streptozotocin(STZ,50mg/kg body weight),confirmed by 12h fasting blood glucose concentration(12mmol/L).The treatment group was subcutaneously injected with protamine zinc insulin(1.8 ~2.2U/animal)at the same time every day.The experiment lasted 32d.Femoral BMD was determined by dual-energy X-ray absorptiometry(DEXA).Serumtestosterone was detected by Enzyme-linked Immunosorbent Assay(ELISA)kit.Total alkaline phosphatase(ALP),calcium (Ca) and phosphorus(P)in serum were measured by bio-machine.Femoral BMDin diabetic group was significantly lower than that in control(P<0.01) but reserved by insulin treatment.Testosterone in serum was also reducedin diabetic rats(P<0.01) and normalized byinsulintreatment.The serum ALP concentration was markedly higher in diabetics(P<0.01) compared with the controls and prevented by insulin treatment.However,no significant differences were observed in serum Ca and P among threegroups.Our results suggest that BMDis seriously affected by diabetes.Insulin deficiency and testosterone decrease are important causes of diabetic osteoporosis.And insulin treatment prevented bone loss and testosterone depression.
%K osteoporosis
%K diabetes mellitus
%K bone mineral density
%K testosterone<br>骨质疏松
%K 糖尿病
%K 骨密度
%K 睾酮
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=B5EDD921F3D863E289B22F36E70174A7007B5F5E43D63598017D41BB67247657&cid=B47B31F6349F979B&jid=67CDFDECD959936E166E0F72DE972847&aid=5FCCC3D5E9A1958E&yid=A732AF04DDA03BB3&vid=B91E8C6D6FE990DB&iid=0B39A22176CE99FB&sid=F9F74EC1AA08A7B9&eid=8B59EA573021D671&journal_id=1002-1175&journal_name=中国科学院研究生院学报&referenced_num=2&reference_num=24