%0 Journal Article
%T Live Virus Vaccines Against Human Respiratory Syncytial Virus<br>人呼吸道合胞病毒活疫苗研究进展
%A HE JinSheng
%A FU YuanHui & HONG Tao
%A College of Life Sciences & Bioengineering
%A Beijing Jiaotong University
%A Beijing
%A China
%A Institute for Viral Disease Control
%A Prevention
%A Chinese Center for Disease Control
%A Prevention
%A Beijing
%A <br>何金生
%A 付远辉
%A 洪涛
%J 中国科学 生命科学
%D 2011
%I 
%X Human respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in infants and young children worldwide, and it is also a significant cause of morbidity and mortality in immunocompromised patients and the elderly. For these reasons, there is a need to develop vaccine effective against RSV. Currently, sereral vaccine development strategies are being explored including subunit vaccines and live virus vaccines, etc. The live virus vaccines, either live attenuated RSV vaccines or live attenuated virus vectors encoding RSV protective antigens (vectored vaccines), are the potential candidate vaccines for seronegative infants, and have been paid more attention. Among them, the rA2cp248/404/1030?SH virus has shown to be highly attentuated and moderately immunogenic in infants no more than two months of age, absent with enhanced RSV disease during subsequent natural RSV infection in the vaccinees. Therefore, the current status and development of RSV live vurs vaccines are reviewed.
%K human respiratory syncytial virus
%K live attenuated RSV vaccines
%K vectored vaccines
%K reverse genetics
%K recombination technology<br>人呼吸道合胞病毒
%K 减毒活疫苗
%K 病毒载体疫苗
%K 反向遗传学
%K 重组技术
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=DBE4ECF0864647819971514F9C47DC38&aid=558C0A01F05DADF8478EED8BD062E853&yid=9377ED8094509821&vid=2001E0D53B7B80EC&iid=CA4FD0336C81A37A&sid=CA4FD0336C81A37A&eid=59906B3B2830C2C5&journal_id=1006-9259&journal_name=中国科学C辑&referenced_num=1&reference_num=0