%0 Journal Article
%T Redox Factor-1 Mediates Inflammatory Response during Tumor Promotion in Skin Epidermal JB6 Cells
%A Delira Robbins
%A Wenjuan Li
%A Katie Humphrey
%A Yunfeng Zhao
%J Open Journal of Apoptosis
%P 19-24
%@ 2168-3840
%D 2012
%I Scientific Research Publishing
%R 10.4236/ojapo.2012.13003
%X <span>Recently, redox factor-1 (Ref-1) has received considerable attention as an enzyme for stimulating tumor cell growth. We hypothesized that Ref-1 is upregulated during the early stage of tumorigenesis. Utilizing both tumor promotion sen</span><span>sitive P+ and promotion resistant P?</span><span> </span><span>mouse skin epidermal JB6 cells, we found that Ref</span><span>-</span><span>1 expression was only induced in tumor promotion sensitive P+ cells following TPA treatment. Consistent with that, Ref-1 knockdown suppressed skin cell transformation. Interestingly, Ref-1 knockdown suppressed nuclear translocation of NF-kappaB subunit p65, and inhibited production of proinflammatory cytokines. These results suggest Ref-1 may promote early tumorigenesis and serve as a target for chemoprevention.</span><span></span>
%K Ref-1
%K Tumorigenesis
%K JB6 Cells
%K Tumor Promotion
%K Chemoprevention
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=23586