%0 Journal Article
%T Regulation of mammalian pre-mRNA splicing<br>
%A HUI JingYi
%A <br>
%J 中国科学C辑(英文版)
%D 2009
%I Springer
%X In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing. Supported by the Program of “one Hundred Talented people” of the Chinese Academy of Sciences.
%K pre-mRNA splicing
%K alternative splicing
%K splicing regulation
%K signal transduction
%K microRNA<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=B7ED7571EC69A354C6C1DADD18CCEF01&yid=DE12191FBD62783C&vid=286FB2D22CF8D013&iid=38B194292C032A66&sid=82722E2B785EBF0D&eid=89AC6B0ADBEA2741&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=92