%0 Journal Article
%T KAI1/CD82 suppresses hepatocyte growth factor- induced migration of hepatoma cells via upregulation of Sprouty2<br>
%A MU ZhenBin
%A WANG Hua
%A ZHANG Jing
%A LI QingFang
%A WANG LiSheng &
%A GUO XiaoZhong
%A <br>
%J 中国科学C辑(英文版)
%D 2008
%I Springer
%X We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis.Hepatocyte growth factor(HGF)induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1(SphK1).Adenovirus-mediated gene transfer of KAI1(Ad-KAI1)downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells.Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level.Ablation of Sprouty2 with RNA interference can block the KAI1/CD82-induced suppression of hepatoma cell migration and downregulation of SphK1 expression.It is demonstrated that KAI1/CD82 suppresses HGF-induced migration of hepatoma cells via upregulation of Sprouty2.
%K KAI1/CD82
%K Sprouty2
%K migration
%K hepatocyte growth factor<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=62386893E441B154F18E785B36928778&yid=67289AFF6305E306&vid=987EDA49D8A7A635&iid=DF92D298D3FF1E6E&sid=421C41B8FD4D3EBA&eid=BBA8B1249CDAA6CE&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=21