%0 Journal Article
%T Association of β-fibrinogen gene -148C/T and -455G/A polymorphisms and coronary artery disease in Chinese population: A Meta analysis<br>
%A CHEN XiaoChao
%A XU MingTong
%A JIN LiZi
%A CHEN Jian &
%A CHEN WeiQing
%A <br>
%J 中国科学C辑(英文版)
%D 2008
%I Springer
%X The purpose of our study was to evaluate the correlation between the beta-fibrinogen gene -148C/T and -455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the -148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the -455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in -148T allele carriers compared to the -148C/C wild-type homozygotes was 1.31 (95%CI: 0.94-1.84, P=0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in -455A allele carriers compared to the -455G/G wild-type homozygotes was 1.75 (95%CI: 1.24-2.46, P=0.001). Our results suggest the absence of an association between the beta-fibrinogen gene -148C/T polymorphism and susceptibility to coronary artery disease and the possibility that -455G/A polymorphism (in particular, allele A) increases susceptibility to this disease in the Chinese population.
%K β
%K -fibrinogen
%K gene polymorphism
%K coronary artery disease
%K myocardial infarction
%K Meta-analysis<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=F170C4C1BE63CEF037A97BB55E992F53&yid=67289AFF6305E306&vid=987EDA49D8A7A635&iid=9CF7A0430CBB2DFD&sid=725C082EB6FD280F&eid=45D68DF69BA881EC&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=22