%0 Journal Article
%T Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid.<br>Androgen receptor coregulator ARA267-α interacts with death receptor-6 revealed by the yeast two-hybrid
%A MAI Tiejun
%A WANG Xin
%A ZHANG Zhiwen
%A XIN Dianqi
%A NA Yanqun
%A GUO Yinglu
%A <br>
%J 中国科学C辑(英文版)
%D 2004
%I Springer
%X ARA267-alpha is a newly identified androgen receptor coactivator. In order to further elucidate its precise role in cells, using the ARA267-alpha fragment containing four PHD and one SET conserved domains as bait we revealed an ARA267-alpha-PHD-SET-interacting protein, death receptor-6 (DR6), in the yeast two-hybrid screening. DR6 is the member of TNF receptor family and has a death domain in its intracellular cytoplasmic portion (DR6cp) to mediate the cell apoptosis. The interaction between ARA267-alpha-PHD-SET and DR6cp was confirmed in vitro and in vivo. Our finding implied that androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-alpha and DR6.
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=4A2CDE96BD3A9FA8943B019EDB9F4BA3&yid=D0E58B75BFD8E51C&vid=F4B561950EE1D31A&iid=94C357A881DFC066&sid=D98387EFB283C5E0&eid=A6683C8C0EB9BCA7&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=0