%0 Journal Article
%T Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers
%A SONG Xin
%A TAO Yongguang
%A ZENG Liang
%A YANG Jing
%A TANG Faqing
%A Leo M Lee
%A GONG Jianping
%A WU Qiao
%A CAO Ya
%A <br>
%J 中国科学C辑(英文版)
%D 2005
%I Springer
%X In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle.
%K latent membrane protein1
%K c-Jun
%K Jun B
%K heterodimer
%K cyclin D1
%K cell cycle<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=0C53BB12E301703B2F127016555053E7&yid=2DD7160C83D0ACED&vid=B6DA1AC076E37400&iid=E158A972A605785F&sid=44FDB9366EDDFA2B&eid=23F20F9780C3579E&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=2&reference_num=41