%0 Journal Article
%T Mechanisms of microRNA-mediated gene regulation<br>
%A ZHAO Shuang&
%A LIU Mo-Fang
%A <br>
%J 中国科学C辑(英文版)
%D 2009
%I Springer
%X microRNAs (miRNAs) are identified as a class of non-protein regulators and a new source for broad control of gene expression in eukaryotes. The past years have witnessed substantial progress in understanding miRNA functions and mechanisms, although a few controversies remain. Various hypotheses and models have been suggested for the mechanisms of miRNA repression, including translational inhibition at the level of initiation or elongation, rapid degradation of the nascent peptide, mRNA degradation, and mRNA sequestration into P bodies (processing bodies) and SGs (stress granules) for degradation or/and storage. Recently, some noncanonical miRNA regulation, such as miRNA activation and de-repression of miRNA inhibition, have been uncovered. This review discusses some recent advances about how miRNAs regulate their targets and various modes of miRNA function.
%K miRNA
%K repression
%K activation
%K de-repression
%K processing bodies
%K stress granules<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=4D327EEB97823F7AAA72AB3C00F1C62F&yid=DE12191FBD62783C&vid=286FB2D22CF8D013&iid=59906B3B2830C2C5&sid=A6B1729CC57A879A&eid=76C32027E03E49D7&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=43