%0 Journal Article
%T Structure comparisons of Aedes albopictus densovirus with other parvoviruses
%A CHENG LingPeng
%A CHEN SenXiong
%A Z H ZHOU &
%A ZHANG JingQiang
%A <br>
%J 中国科学C辑(英文版)
%D 2007
%I Springer
%X Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by elec-tron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure compari-sons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity be-tween C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other in-sect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses.
%K densovirus
%K three-dimensional structure
%K amino acid sequence<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=399F4AF0453AD605304139A814E3C473&yid=A732AF04DDA03BB3&vid=771152D1ADC1C0EB&iid=CA4FD0336C81A37A&sid=09ABD5535D9B6D45&eid=67969BA850333433&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=2&reference_num=23