%0 Journal Article
%T Fast repair of purine deoxynucleotide radical cations by rutin and quercetin
%A Chenyang Zhao
%A Yimin Shi
%A Wenfeng Wang
%A Zhongjian Jia
%A Side Yao
%A Botao Fan
%A Rongliang Zheng
%A <br>赵晨阳
%A 石益民
%A 王文锋
%A 贾忠建
%A 姚思德
%A 范波涛
%A 郑荣梁
%J 中国科学C辑(英文版)
%D 2001
%I Springer
%X Repair effects of rutin and quercetin on purine deoxynucleotide radical cations were studied using pulse radiolysis technique. On electron pulse irradiation of N2 saturated deoxynucleotide aqueous solution containing 20 mmol/L K2S2O8, 200 mmol/Lt-BuOH and rutin or quercetin, the transient absorption spectra of the deoxynucleotide radical cations decayed quickly. At the same time, the spectra of flavonoid phenoxyl radicals formed within several dozen microseconds. The results indicated that deoxynucleotide radical cations can be repaired by flavonoids. The rate constants of the repair reactions were 3.8 ×108-4.4 ×108 mol 1 · L · s 1 and 1.3×108-1.8×108 mol 1 · L · s 1 for dAMP and dGMP radical cations, respectively.
%K DNA damage
%K deoxynucleotide radical cation
%K repair
%K electron transfer
%K rutin
%K quercetin<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=00BA41ADE69FDD28B95161A502390089&yid=14E7EF987E4155E6&vid=1AE5323881A5ECDC&iid=B31275AF3241DB2D&sid=44E78A5D1B37D836&eid=7FAAB0292FA0D5D0&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=2&reference_num=24