%0 Journal Article
%T Atomic force microscopy study of the rabbit skeletal muscle ryanodine receptors in different functional states<br>Atomic force microscopy study of the copy rabbit skeletal muscle ryanodine receptors in different functional states
%A WEI Qingqing
%A CHENG Xiaoyang
%A CHEN Keying
%A HU Jun
%A LI Minqian
%A ZHU Peihong
%A <br>魏青青
%A 程晓阳
%A 陈克樱
%A 胡钧
%A 李民乾
%A 朱培闳
%J 中国科学C辑(英文版)
%D 2002
%I Springer
%X Atomic force microscope was applied to investigate the effect of extrinsic phospholipid on the structure of rabbit skeletal muscle ryanodine receptor/calcium release channel (RyR1). In addition, in the presence of extrinsic phospholipid, the height and elasticity of the RyR1s in different functional states were also measured. The results indicate: (i) most of the RyR1s showed a normal structure only in the presence of extrinsic phospholipid; (ii) treatment of the RyR1s with AMP and Ca2+ together could increase their Young's Modulus but not change their apparent height; (iii) no detectable change in either height or Young's Modulus of the RyR1s appeared, if the RyR1s were treated with other activators or inhibitors.
%K ryanodine receptor/calcium release channel
%K atomic force microscope
%K elasticity<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=8A0745BFC69AC96BF225680D1F258432&yid=C3ACC247184A22C1&vid=94E7F66E6C42FA23&iid=38B194292C032A66&sid=4966445AEEBA9556&eid=FBCA02DBD05BD4EA&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=1&reference_num=31