%0 Journal Article
%T Gamma-aminobutyric acid and GABAA receptors are involved in directional selectivity of pretectal neurons in pigeons<br>
%A XIAO Quan
%A FU Yuxi
%A HU Jing
%A GAO Hongfeng
%A WANG Shurong
%A <br>
%J 中国科学C辑(英文版)
%D 2000
%I Springer
%X The present study describes the effects of gamma-aminobutyric acid (GABA) and its antagonists, bicuculline and 2-hydroxysaclofen, on visual responses of neurons in the pigeon nucleus lentiformis mesencephali (nLM). The results indicate that GABA significantly reduces both spontaneous activity and visual responsiveness, and GABAA antagonist bicuculline but not GABAB antagonist 2-hydroxysaclofen enhances visual responses of nLM cells examined. Furthermore, inhibition produced by motion in the null-direction of pretectal neurons is diminished by bicuculline but not by 2-hydroxysaclofen. It is therefore concluded that the null-direction inhibition of directional cells in the pigeon nLM is predominantly mediated by GABA and GABAA receptors. This inhibition may at least in part underlie directional asymmetry of optokinetic responses.
%K directional selectivity
%K GABA
%K nucleus lentiformis mesencephali
%K optokinetic nystagmus
%K pigeon<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=E6E16FC2B9BE51FFBB35268CFE8C92F6&yid=9806D0D4EAA9BED3&vid=BE33CC7147FEFCA4&iid=38B194292C032A66&sid=5D8C08279A19B0D4&eid=11CEECA6DA9E4AC5&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=15