%0 Journal Article
%T Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Δ 32, CCR2-64I, and SDF1-3 A) in China<br>
%A XIAO Junhua HU Fang
%A XU Hongyan
%A SU Bing
%A JIANG Yueming
%A LUO Jingchun
%A ZHANG Weiling
%A TAN Jiazhen
%A JIN Li
%A LU Daru
%A <br>
%J 中国科学C辑(英文版)
%D 2000
%I Springer
%X CCR5-Δ32, CCR2-64I, mutants in two chemokine receptors and SDF1-3′A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Δ 32 was observed. CCR2-64I and SDF1-3′ A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.
%K HIV-1
%K AIDS
%K PCR-RFLP<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=FC2DF691F3D1F14BA3AD04F08252B3E0&yid=9806D0D4EAA9BED3&vid=BE33CC7147FEFCA4&iid=CA4FD0336C81A37A&sid=7801E6FC5AE9020C&eid=A04140E723CB732E&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=9