%0 Journal Article
%T Effects of dragon’s blood resin and its component loureirin B on tetrodotoxinsensitive voltage-gated sodium currents in rat dorsal root ganglion neurons<br>Effects of dragon’s blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons
%A LIU Xiangming
%A CHEN Su
%A YIN Shijin
%A MEI Zhinan
%A <br>
%J 中国科学C辑(英文版)
%D 2004
%I Springer
%X Using whole-cell patch clamp technique on the membrane of freshly isolated dorsal root ganglion (DRG) neurons, the effects of dragon's blood resin and its important component loureirin B on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents were observed. The results show that both blood resin and loureirin B could suppress TTX-S voltage-gated sodium currents in a dose-dependent way. The peak current amplitudes and the steady-state activation and inactivation curves are also made to shift by 0.05% blood resin and 0.2 mmol/L loureirin B. These results demonstrate that the effects of blood resin on TTX-S sodium current may contribute to loureirin B in blood resin. Perhaps the analgesic effect of blood resin is caused partly by loureirin B directly interfering with the nociceptive transmission of primary sensory neurons.
%K blood resin
%K loureirin B
%K dorsal root ganglion neurons
%K tetrodotoxin-sensitive sodium channel<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=B076668FEB16822BC8BF41EB5762DE2C&yid=D0E58B75BFD8E51C&vid=F4B561950EE1D31A&iid=E158A972A605785F&sid=9D9F10A828991FA6&eid=375BEEEA164CFE59&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=17