%0 Journal Article
%T Prediction on the binding domain between human interleukin-6 and its receptor
%A FENG Jiannan REN Yunfang
%A SHEN Beifen
%A <br>冯健男
%A 任蕴芳
%A 沈倍奋
%J 中国科学C辑(英文版)
%D 2000
%I Springer
%X Based on the spatial conformations of human interleukin-6 (hlL-6) derived from nuclear magnetic resonance analysis and human interleukin-6 receptor (hlL-6R) modeled with homology modeling method using human growth hormone receptor as template, the interaction between hlL-6 and its receptor (hIL-6R) is studied with docking program according to the surface electrostatic potential analysis and spatial conformation complement. The stable region structure composed of hlL-6 and hlL-6R is obtained on the basis of molecular mechanism optimization and molecular dynamics simulation. The binding domain between hIL-6 and hIL-6R is predicted theoretically. Furthermore, the especial binding sites that influence the interaction between hlL-6 and hlL-6R are confirmed. The results lay a theoretical foundation for confirming the active regions of hlL-6 and designing novel antagonist with computer-guided techniques.
%K human interleukin-6
%K human interleukin-6 receptor
%K surface electrostatic potential
%K docking<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=8FA861688CC9D7B8&yid=9806D0D4EAA9BED3&vid=BE33CC7147FEFCA4&iid=E158A972A605785F&sid=0493D643315CD829&eid=84A93BA251D28205&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=1&reference_num=12