%0 Journal Article
%T 126Gln is the residue of human IL-2 binding to IL-2R γ subunit<br>
%A WANG Zhiyong
%A ZHENG Zhongcheng
%A SUN Lanying
%A LIU Xinyuan
%A <br>
%J 中国科学C辑(英文版)
%D 1997
%I Springer
%X The 126Gln of human interleukin-2 (IL-2) is a conserved amino acid residue. After substitution of 126Gln with Asp, the binding abilities of this mutant to different composites of IL-2 receptor (R) subunits have been determined. Results show that 126AspIL-2 has higher affinity to IL-2R α β γ complex and normal affinity to IL-2R α β complex, but loses its binding ability to IL-2R β γ complex, demonstrating that the 126Gln is the residue of human IL-2 which binds to IL-2R γ subunit. Project supported by the “863” Project of China.
%K IL-2
%K IL-2R
%K binding site<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=E45EB1A1A249780746F7C225EA2F277B&yid=5370399DC954B911&vid=1371F55DA51B6E64&iid=0B39A22176CE99FB&sid=BA79719BCA7341D5&eid=BBF7D98F9BEDEC74&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=0