%0 Journal Article
%T Ectopic discharges trigger sympathetic sprouting in rat dorsal root ganglia following peripheral nerve injury
%A DONG Chenghai
%A XIE Zuolei
%A FAN Jiyun
%A XIE Yikuan
%A <br>董承海
%A 谢作磊
%A 樊继云
%A 谢益宽
%J 中国科学C辑(英文版)
%D 2002
%I Springer
%X Experimental backgrounds of ectopic discharges were made by i.p. administrating of 4-aninopyriding (4-AP), a K+ channel blocker, or anisodamine, a muscarinic receptor blocker, in CCI rats, and the sympathetic sprouting in the dorsal root ganglia (DRG) as well as the heat-hyperalgesia was observed. It was demonstrated that the increased ectopic discharges induced by 4-AP promote sympathetic sprouting in the DRG and a greater number of sympathetic basket cells were developed, causing exacerbation of heat-hyperalgesia in CCI rats. On the contrary, the sympathetic sprouting in the DRG and heat-hyperalgesia are evidently diminished after anisodamine injection. Our results suggest that ectopic discharges may be an immediate factor in triggering sympathetic sprouting in DRG following peripheral nerve injury.
%K sympathetic sprouting
%K nerve injury
%K ectopic discharge<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=A0089E8D62A6193A2A6AA2A6B9707407&yid=C3ACC247184A22C1&vid=94E7F66E6C42FA23&iid=0B39A22176CE99FB&sid=AC1578C6BB9EBDEF&eid=1E41DF9426604740&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=1&reference_num=22