%0 Journal Article
%T β-adrenergic modulation of in vivo long-term potentiation in area CA1 and its role in spatial learning in rats
%A JI Jinzhao
%A ZHANG Xuehan LI Baoming
%A <br>
%J 中国科学C辑(英文版)
%D 2003
%I Springer
%X Activation of beta-adrenoceptors in area CA1 of the hippocampus facilitates in vitro long-term potentiation (LTP) in this region. However, it is unclear if in vivo LTP in area CA1 and hippocampus-dependent learning are subjected to beta-adrenergic regulation. To address this question, we investigated the effects of the beta-adrenergic agonist L-isoproterenol or antagonist DL-propranolol on in vivo LTP of area CA1 and the spatial learning in Morris water maze. In the presence of L-isoproterenol (through local infusion into area CA1), the theta-pulse stimulation with the parameter of 10 Hz, 150 pulses/train, 1 train, a frequency weakly modifying synaptic strength, induced a robust LTP, and this effect was blocked when DL-propranolol was co-administered. By contrast, the theta-pulse stimulation with the parameter of 5 Hz, 150 pulses/train, 3 trains, a frequency strongly modifying synaptic strength, induced a significantly smaller LTP when DL-propranolol was administered into area CA1. Accordingly, DL-propranolol impaired the spatial learning in the water maze when infused into area CA1 20 min pretraining. Compared with control rats, the DL-propranolol-treated rats showed significantly slower learning in the water maze and subsequently exhibited poor memory retention at 24-h test. These results suggest that beta-adrenoceptors in area CA1 are involved in regulating in vivo synaptic plasticity of this area and are important for spatial learning.
%K β
%K -adrenoceptor
%K long-term potentiation
%K CA1
%K hippocampus
%K spatial learning
%K rat<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=87B5B10317E86E503EF8F7C510D30365&yid=D43C4A19B2EE3C0A&vid=D997634CFE9B6321&iid=B31275AF3241DB2D&sid=10A39635766FF5D0&eid=2C20277AC27E4821&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=25