%0 Journal Article
%T The role of hepatitis B virus x gene in development of primary hepatocellular carcinoma
%A TAO Xiaohong SHEN Dingming
%A REN Hong
%A ZHANG Xiaoshi
%A ZHANG Dazhi
%A GU Baiyan
%A YE Jia
%A <br>陶小红
%A 沈鼎明
%A 任红
%A 张晓实
%A 张大志
%A 古柏燕
%A 叶珈
%J 中国科学C辑(英文版)
%D 2000
%I Springer
%X Primary hepatocellular carcinoma (HCC) is one of the most common cancers occurring in human, and there is strong epidemiological evidence suggesting that persistent hepatitis B virus (HBV) infection is the most important risk factor for its development. HBx gene was found to be a transactivator recently. Its continuous expression in hepatocytes may transactivate cellular genes which can play a certain role in development of HCC. The HBx gene fragment was used to construct a recombinant eukaryotic expression vector pCEP4 and introduced into HepG2 cells. The effect of HBx gene on HCC cells growth and its molecular mechanism in HCC cells regulation were investigated.
%K HBx gene
%K carcinogenesis
%K hepatocellular carcinoma
%K IGF-IR
%K VEGF
%K P21~(CIP1/WAF1)
%K PCNA
%K cell cycle<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=C9F840DC9B915060&yid=9806D0D4EAA9BED3&vid=BE33CC7147FEFCA4&iid=38B194292C032A66&sid=2AC7DCCBBC26ECF8&eid=DFEE4E8C33C95CEF&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=27