%0 Journal Article
%T Cloning and characterization of a novel member of human β-1,4-galactosyltransferase gene family<br>
%A FAN Yuxin
%A YU Long
%A ZHANG Qi
%A JIANG Ying
%A DAI Fangyan
%A CHEN Chiyuan
%A TU Qiang
%A BI Anding
%A XU Yuefang
%A ZHAO Shouyuan
%A <br>
%J 中国科学C辑(英文版)
%D 1999
%I Springer
%X By using the EST strategy for identifying novel members belonging to homologous gene families, a novel fulklength cDNA encoding a protein significantly homologous to UDP-Gal: N-acetylglucosamine β-1, 4-galactosyltransferase (GalT) was isolated from a human testis cDNA library. A nucleotide sequence of 2 173 bp long was determined to contain an open reading frame of 1 032 nucleotides (344 amino acids). In view of the homology to memben of the galactosyltransferase gene family and especially the closest relationship toGallus gallus GalT type I (CK I), the predicted product of the novel cDNA was designated as human β-1,4-galactosyltransferase homolog I (HumGT-H1). Its mRNA is present in different degrees in 16 tissues examined. Southern analysis of human genomic DNA revealed its locus on chromosome 3. Poject supported by the 863 High-technology Program, the National Outstanding Young Scientist Foundation and the National Natural Science Foundation of China (Grant No. 39680019).
%K β
%K -1
%K 4-galactosyltransferase
%K cDNA
%K homolog<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=50685C699415959CE7716DF3925FFA1C&yid=B914830F5B1D1078&vid=ECE8E54D6034F642&iid=E158A972A605785F&sid=5FF9F4F7CB1800C7&eid=3622B70F9C54A9CC&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=19