%0 Journal Article
%T Characterization of a murine thymic CD4+ T cell subset-TCRαβ+ 3G11-6C10- CD4+ CD8-thymocytes<br>
%A GE Qing
%A CHEN Weifeng
%A <br>
%J 中国科学C辑(英文版)
%D 1999
%I Springer
%X The presence of a relatively mature CD4+ CD8  (SP) T cell subset in mouse thymus has been demonstrated. Composing of 10% of total CD4SP thymocytes, this subset is defined by the absence of 3G11 and 6C10 expression with a phenotype of CD69+/ , HSAmed/lo and heterogeneous for Qa-2 expression. The proliferation capability of TCRαβ+ 3Gl l  6C10  CD4+ CD8  thymocytes was high while using Con A stimulus. And Con A stimulation could result in secretion of IL4, IL-10, IL-6 and a little amount of IFNγ. IL-2 was barely detectable. This is distinct from typical Th0 type cytokines. The cells of this subset were NK1.1 negative, but strongly expressed GATA-3 mRNA. The results suggest that the CD4+ subset of 3G11  6C10  NK1.1  phenotype possesses immunocompetent cells with functions characteristic of Th2-like cytokines, which may indicate the cells at transitional status from Th0 to Th2, with a propensity to Th2. Project supported by the National Natural Science Foundation of China (Grant No. 39730410).
%K TCRα
%K β
%K + 3G11
%K 6C10
%K CD4+ CD8
%K thymocytes
%K phenotype
%K cytokine<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=24E2BA00A8669D7019A519138FE99EBC&yid=B914830F5B1D1078&vid=ECE8E54D6034F642&iid=E158A972A605785F&sid=5319469C819FCFF1&eid=A6683C8C0EB9BCA7&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=14