%0 Journal Article
%T Effect of adeno-associated virus-mediated transfer of low density lipoprotein receptor gene on treatment of hypercholesterolemia<br>
%A CHEN Guanghui
%A SONG Liangwen
%A ZHU Xiaojun
%A ZHANG Xiaoy ZHANG Chenhui
%A WANG Tailing
%A TANG Jian
%A <br>
%J 中国科学C辑(英文版)
%D 1998
%I Springer
%X Low density lipoprotein receptor (LDL\|R) plays an important role in removing LDL from plasma and preventing producing atherosclerosis. To test hepatic reconstitution of LDL\|R expression is sufficient for metabolic correction of subjects with hypercholesterolemia; a recombinant adeno\|associated virus (rAAV) carrying the human LDL receptor cDNA (AAV/LDL\|R) was constructed. Using adenosome, a complex of adenoviral capsid protein and liposome, to transfer the rAAV into livers of rabbits with experimental hypercholesterolemia could elicit the production of LDL\|R and lower plasma cholesterol level. These results demonstrate that AAV\|mediated transfer of LDL\|R gene may provide an alternative means to gene therapy of hypercholesterolemia.
%K LDL\|R
%K adeno\|associated virus
%K gene therapy<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=180CF3A72E750F3261A8A60EDC957784&aid=4A206EBC8AB9FDCB24D680F9DBD3C443&yid=8CAA3A429E3EA654&vid=2001E0D53B7B80EC&iid=E158A972A605785F&sid=8D75AD3BD0D1BCC5&eid=5319469C819FCFF1&journal_id=1674-7305&journal_name=ScienceChina.Lifesciences&referenced_num=0&reference_num=7