%0 Journal Article
%T Association study of an (AC)n dinucleotide repeat and schizophrenia in Asian and European populations<br>在亚洲和欧洲人群中对一个AC二核苷酸重复的多态性位点与精神分裂症的关联研究
%A David St Clair
%A MA Jie
%A FAN Jin-Bo
%A WU Sheng-Nan
%A ZHANG Chang-Shun
%A JI Bao-Hu
%A WANG Lei
%A LI Xing-Wang
%A GU Niu-Fan
%A FENG Guo-Yin
%A David St Clair
%A HE Lin
%A <br>马捷
%A 樊金波
%A 吴胜男
%A 张长顺
%A 纪宝虎
%A 王磊
%A 李兴旺
%A 顾牛范
%A 冯国鄞
%A David St Clair
%A 贺林
%J 遗传
%D 2007
%I 
%X Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (AC)n dinucleotide repeat polymorphism at D15S118 and schizophrenia was investigated using three independent samples from the Han Chinese population and the Scotland population. In the popula- tion-based study, a significant difference was found between the allele frequency distributions in schizophrenia patients andcontrol subjects in the Scottish samples (P = 0.04), but was not replicated in the Chinese samples. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Overall, our re- sults did not support the hypothesis that the (AC)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility, at least in the Chinese population. Further studies are needed to elucidate its role in schizophrenia susceptibi- lity in European population.
%K D15S118<br>精神分裂症
%K 关联
%K 传递不平衡(TDT)
%K α-7烟碱受体亚基基因(cHRNA7)
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=49885AD3A60776E4&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=F3090AE9B60B7ED1&sid=86CBF6E43FA9E551&eid=E5572679EEAEEC9C&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=38