%0 Journal Article
%T Expression of cell cycle related proteins cyclin D1, p53 and p21WAF1/Cip1 in esophageal squamous cell carcinoma<br>细胞周期相关蛋白cyclin D1、p53和p21WAF1/Cip1在食管鳞癌中的表达改变及其病理学意义
%A 林德晨
%A 史志周
%A 薛丽燕
%A 陈微
%A 徐昕
%A 韩亚玲
%A 吕宁
%A 王明荣
%J 遗传
%D 2010
%I 
%X Dysregulation of cell cycle control, especially G1/S phase transition, is implicated in the pathogenesis of most human cancers, including esophageal squamous cell carcinoma (ESCC). However, the clinicopathological significance of aberrant expression of G1/S phase-related proteins in ESCC remains unclear. In the present study, cyclin D1, p21WAF1/Cip1 and p53 protein expression were examined in 148 ESCC cases using immunohistochemistry combined with tissue microarray. We then analyzed the correlations between their expression and clinicopathological parameters and found that overexpression of p53 was associated with lymph node metastasis (P = 0.001). p21WAF1/Cip1 down-regulation was an independent prognostic factor by multivariate analysis (RR = 0.418, P <0 .001). Further more, array-CGH results revealed that cyclin D1 gene was amplified in 45.4% of ESCC patients. This study confirms that dysregulation of G1/S related genes is common in ESCC and reduced expression of p21WAF1/Cip1 protein can predict shorter overall survival time of patients with ESCC.
%K 食管鳞状细胞癌
%K 细胞周期
%K 免疫组化
%K 组织微阵列
%K 预后判断
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=63989B91611FFC7525D5088493E6CBE5&yid=140ECF96957D60B2&vid=9971A5E270697F23&iid=94C357A881DFC066&sid=366B1248A15658C5&eid=E0172F1A638CE984&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=22