%0 Journal Article
%T Progress in epidermal stem cells<br>表皮干细胞研究进展
%A WANG Li-Juan
%A WANG You-Liang
%A YANG Xiao
%A <br>王丽娟
%A 王友亮
%A 杨晓
%J 遗传
%D 2010
%I 
%X Mammalian skin epidermis contains different epidermal stem cell pools which contribute to the homeostasis and repair of skin epithelium. Epidermal stem cells possess two essential features common to all stem cells: self-renewal and differentiation. Disturbing the balance between self-renewal and differentiation of epidermal stem cell often causes tumors or other skin diseases. Epidermal stem cell niches provide a special microenvironment that maintains a balance of stem cell quiescence and activity. This review primarily concentrates on the following points of the epidermal stem cells: the existing evidences, the self-renewal and differentiation, the division pattern, the signal pathways regulating self-renewal and differentiation, and the microenvironment (niche) and macroenvironment maintaining the homeostasis of stem cells.
%K epidermal stem cell
%K self-renewal
%K differentiation
%K division paHern
%K signal pathway
%K microenvironment and macroenvironment<br>表皮干细胞
%K 自我更新
%K 分化
%K 分裂模式
%K 信号通路
%K 微观环境与宏观环境
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=E6C7E613339701F7AA4F2C0A11F80154&yid=140ECF96957D60B2&vid=9971A5E270697F23&iid=38B194292C032A66&sid=FEF02B4635FE8227&eid=02DC3A182A5530DF&journal_id=0253-9772&journal_name=遗传&referenced_num=2&reference_num=44