%0 Journal Article
%T The Study of HLA-Cw Polymorphism in Uygur Population<br>新疆维吾尔族HLA-Cw基因座遗传多态性调查 The Study of HLA-Cw Polymorphism in Uygur Population
%A Hong-Bo Zhang
%A Jun-Hai Zhao
%A Jiang-Hua Lai
%A Teng Chen
%A Sheng-Bin Li
%A Shu-Ping Lai
%A <br>张洪波
%A 赵钧海
%A 赖江华
%A 陈腾
%A 李生斌
%A 赖淑苹ZHANG Hong-Bo
%A ZHAO Jun-Hai
%A LAI Jiang-Hua
%A CHEN Teng
%A LI Sheng-Bin
%A LAI Shu-Ping
%J 遗传
%D 2003
%I 
%X The HLA-Cw loci polymorphism in Uygur population was investigated using the PCR- sequence specific oligonucleotide probe (SSOP) method,and the genetic database on the distribution of gene frequency of the HLA-Cw loci was established.From 146 individuals of Uygur population,18 HLA-Cw alleles were detected.The gene frequency was from 0.0069 to 0.2460.The four most common alleles were HLA-Cw*04(24.60%),07(11.51%),08(10 10%),14(12.02%),and they covered 58.23% of total alleles detected from Uygur population.We have made a survey of HLA-Cw alleles frequencies in a Uygur population,with blank frequency being lowered to 0.0064.The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by hi-square test.The frequency data can be used in forensic and paternity tests to estimate the frequency of a DNA profile in the Uygur population,transplant matching and anthropology.
%K HLA-Cw
%K PCR-SSOP
%K polymorphism
%K Uygur population<br>新疆维吾尔族
%K HLA-Cw基因座
%K 遗传多态性
%K 基因分型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=85CB014DA89F0E4A&yid=D43C4A19B2EE3C0A&vid=C5154311167311FE&iid=94C357A881DFC066&sid=811ACA5D3673A764&eid=CEFF71AEB051114C&journal_id=0253-9772&journal_name=遗传&referenced_num=8&reference_num=12