%0 Journal Article
%T Use of Apc(Min/+) mouse model in the studies of intestinal tumors<br>Min基因突变小鼠模型在肠道肿瘤研究中的应用
%A SHENG Hong-Qiang
%A CHEN Jian
%A LAI Mao-De
%A <br>盛弘强
%A 陈俭
%A 来茂德
%J 遗传
%D 2008
%I 
%X More than thirty kinds of mutant or knockout mice bearing intestinal neoplasm have been reported up to the present. Apc(Min/+) mouse holding multiple intestinal neoplasia, provides an appropriate model to evaluate human familial adenomatous polyposis. APC is an important tumor-suppressor gene in the Wnt pathway, which is involved in the pivotal signal transduction cascade in animal embryogenesis and colorectal carcinogenesis. Apc(Min/+) mouse model was presented as aspects of the strain background, genotype/phenotype, divergent canonical Wnt signaling pathway, methylation of tumor-suppressor gene, TGF-b signaling pathway and multidrug resistance gene, etc. This review also introduced the application and signification of the mouse model in studies of anti-colorectal tumor drugs.
%K APC基因
%K Min小鼠
%K Wnt基因
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=BB4939870CD6E20DA02E798C13A5143A&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=38B194292C032A66&sid=CAA7BAE04CB631A1&eid=4133DDB79B497495&journal_id=0253-9772&journal_name=遗传&referenced_num=3&reference_num=42