%0 Journal Article
%T miR-34s—a tumor suppression protein p53 highly related microRNA<br>miR-34家族——-肿瘤抑制蛋白p53高度相关microRNA
%A 娄文加
%A 陈青
%A 刘立
%A 钱程
%J 遗传
%D 2010
%I 
%X Several microRNAs, most representatively the miR-34, are highly related to tumor suppression protein p53. p53 exerts its tumor suppression function known as inhibiting multiple-oncogenes, such as Bcl-2, c-myc and cell cytokines such as cyclinE2, cyclinD1 and c-Met through the regulation of miR-34. On the other hand, miR-34 enhances the activities of p53 by inhibiting silence information regulator I (SIRTI). The positive feedback regulatory network based on p53 and miR-34 families play an important role in suppression of oncogenesis and deterioration. This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment.
%K miR-34家族
%K p53
%K 反馈调节
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=372DFB8588BEA17D01E242C6843DBCD8&yid=140ECF96957D60B2&vid=9971A5E270697F23&iid=94C357A881DFC066&sid=F27A401E323B6FAD&eid=389DA78D878702A9&journal_id=0253-9772&journal_name=遗传&referenced_num=2&reference_num=39