%0 Journal Article
%T Somatic cell nuclear transfer and centrosome inheritance<br>体细胞核移植与中心体遗传
%A DU Wei-Hua
%A ZHU Hua-Bin
%A HAO Hai-Sheng
%A WANG Dong
%A <br>杜卫华
%A 朱化彬
%A 郝海生
%A 王栋
%J 遗传
%D 2008
%I 
%X The developmental competence of embryos cloned from somatic cells depends on the cellular event and molecular process, such as separation of chromosomes and reorganization of spindle after nuclear transfer. Centrosome, the main microtubule organizing centers in a cell, is crucial for reorganization of spindle and normal separation of chromosomes during mitosis. Aberrant of centrosomes will lead to aneuploidy of blastomere and developmental failure of embryo. This paper expounded the situation of animal somatic cell nuclear transfer (SCNT) and biological functions of centrosome and analyzed the inheritance mechanism of centrosome during gametogenesis and fertilization. Additionally, the study condition of centrosome and its associated proteins in SCNT embryos were introduced, which provided a new clue to study the de-velopmental abnormality of cloned embryos and animals.
%K 体细胞核移植
%K 胚胎发育
%K 中心体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=4CD6AA2171BDE7AB1E62F3462046362C&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=5D311CA918CA9A03&sid=40700C9CB4E84E3B&eid=7EEA6F8DDD9FAD6E&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=46