%0 Journal Article
%T The Application of RNAi Technology in Transgenic Mice<br>RNAi技术在转基因动物中的应用
%A YIN Xiu-Shan
%A ZHANG Ling-Qiang
%A HE Fu-Chu
%A <br>尹秀山
%A 张令强
%A 贺福初
%J 遗传
%D 2006
%I 
%X RNA interference(RNAi) has been extensively used for sequence-specific silencing of gene function in C.(elegans,) Drosophila, mouse and rat.The generation of RNAi transgenic mice made it possible to knock down gene expression at the whole organism level in mammalian species.In this review we described the design strategy of RNAi vectors,compared the difference of gene knock-down from knock-out,and summarized the advantages and unresolved issues concerning RNAi transgenic mice.The contribution of RNAi transgenic mice to functional genomics and of its prospect for application were also discussed.
%K RNAi<br>转基因小鼠
%K 基因打靶
%K 模式生物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=F8F51F814083375D&yid=37904DC365DD7266&vid=D3E34374A0D77D7F&iid=38B194292C032A66&sid=381FB4265090A8E0&eid=35E8A259891FB32F&journal_id=0253-9772&journal_name=遗传&referenced_num=3&reference_num=32