%0 Journal Article
%T Studies of the Relationship of HLA Polymorphisms and the Infection of H.pylori in the Population of Linqu in Shandong Province<br>山东临朐人群HLA等位基因多态性与幽门螺杆菌感染关系的研究Studies of the Relationship of HLA Polymorphisms and the Infection of H.pylori in the Population of Linqu in Shandong Province
%A LI Zhao-Hui~
%A WANG Zhan-Min~
%A ZHANG Lian~
%A PAN Kai-Feng~
%A ZHANG Chun-Feng~
%A NING Tao~
%A KE Yang~
%A <br>李昭辉
%A 王占民
%A 张联
%A 潘凯枫
%A 张春凤
%A 宁涛
%A 柯杨LI Zhao-Hui
%A WANG Zhan-Min
%A ZHANG Lian
%A PAN Kai-Feng
%A ZHANG Chun-Feng
%A NING Tao
%A KE Yang
%J 遗传
%D 2004
%I 
%X In order to analyze the relationship of HLA polymorphisms and the infection of H. pylori in the population of Linqu County in Shandong Province, polymerase chain reaction with sequence-specific primers(PCR-SSP) was used to determine the alleles of HLA type I and II in 90 Hp-positive persons and 49 Hp-negative controls. The results showed that among the 68 alleles of HLA type I ,4 alleles were found significantly different between Hp-positive and Hp-negative population,while no significant difference was found among the 22 alleles of HLA type UI. Hp-positive persons had a lower allele frequency of A* 02 (OR=0.56, 95% CI=0.33 approximately 0. 94; P=0.029), B* 48 (OR=0.15, 95% CI=0.03 approximately 0.72; P=0. 007), CW* 08 (OR=0. 32, 95% CI=0.15 approximately 0.69; P=0. 003) and a higher allele frequency of CW* 15 (OR=5.11, 95% CI=0.63 approximately 40.90; P=0. 024) compared with Hp-negative controls. Our results indicated that the polymorphisms of HLA type I is involved in the genetic susceptibility of Hp infection in Linqu County,while the polymorphisms of HLA type I may have no relationship with the genetic susceptibility of Hp infection. It was shown that among the alleles of HLA type I , CW* 15 might be a susceptible gene of Hp infection while A * 02 ,B * 48 and CW* 08 might be protective genes.
%K PCR-SSP<br>人类白细胞抗原(HLA)
%K 幽门螺杆菌
%K 遗传易感性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=8E7AB7D0D559C234&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=0B39A22176CE99FB&sid=475189FCB44F11F6&eid=A020552C37306588&journal_id=0253-9772&journal_name=遗传&referenced_num=4&reference_num=18