%0 Journal Article
%T Sequence polymorphism of mtDNA HVR Ⅰ and HVR Ⅱ of Oroqen ethnic group in Inner Mongolia<br>中国内蒙古鄂伦春族线粒体DNA高变区Ⅰ和高变区Ⅱ遗传多态性
%A YAN Chun-Xia
%A CHEN Feng
%A DANG Yong-Hui
%A LI Tao
%A ZHENG Hai-Bo
%A CHEN Teng
%A LI Sheng-Bin
%A <br>阎春霞
%A 陈峰
%A 党永辉
%A 李涛
%A 郑海波
%A 陈腾
%A 李生斌
%J 遗传
%D 2008
%I 
%X Venous blood samples from 50 unrelated Oroqen individuals living in Inner Mongolia were collected and their mtDNA HVR I and HVR II sequences were detected by using ABI PRISM377 sequencers. The number of polymorphic loci, haplotype, haplotype frequence, average nucleotide variability and other polymorphic parameters were calculated. Based on Oroqen mtDNA sequence data obtained in our experiments and published data, genetic distance between Oroqen ethnic group and other populations were computered by Nei's measure. Phylogenetic tree was constructed by Neighbor Joining method. Comparing with Anderson sequence, 52 polymorphic loci in HVR I and 24 loci in HVR II were found in Oroqen mtDNA sequence, 38 and 27 haplotypes were defined herewith. Haplotype diversity and average nucleotide variability were 0.964+/-0.018 and 7.379 in HVR I, 0.929+/-0.019 and 2.408 in HVR II respectively. Fst and dA genetic distance between 12 populations were calculated based on HVR I sequence, and their relative coefficients were 0.993(P < 0.01). A phylogenetic tree was constructed based on genetic distances and included Oroqen, Taiwan and South Han population in a clade, which indicated near genetic relation between them, and far relation with northern Han, Mongolian and other foreign populations. The genetic polymorphism of mtDNA HVR I and HVR II in Oroqen ethnic group has some specificities compared with that of other populations. These data provide a useful tool in forensic identification, population genetic study and other research fields.
%K 鄂伦春族
%K 线粒体DNA
%K 高变区Ⅰ
%K 高变区Ⅱ
%K 遗传多态性
%K 遗传距离
%K 聚类分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=4AE9C123FC64560B9831E3AD6DE86FAA&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=E158A972A605785F&sid=AC2617B68B137D9D&eid=C66DE7562B0326E2&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=22