%0 Journal Article
%T Cytochrome P450 2C19 Gene Polymorphism in 104 Chinese Zang Volunteers<br>104名藏族志愿者中细胞色素P450 2C19m1的基因多态性Cytochrome P450 2C19 Gene Polymorphism in 104 Chinese Zang Volunteers
%A DING Hua-Wen
%A DONG Zhao-Wen
%A JIANG Zu-Gang
%A MA Xu
%A <br>丁华文
%A 董兆文
%A 姜祖刚
%A 马旭
%J 遗传
%D 2004
%I 
%X Cytochrome P 450 2C19 (CYP2C19) is involved in the metabolism of a number of clinically used drugs. Individuals can be characterized as extensive metabolizers (EMs) or poor metabolizers (PMs) , according to the drugs-metabolized ability of CYP2C19 in population studies. The incidence of poor metabolizer phenotype shows marked interracial differences. In this article we report the gene polymorphism of CYP2C19 in Zang population. There were 49 wild-type homozygotes (wt/wt) , 46 were heterozygotes (wt/m1) and 9 were homozygotes (m1/m1) among 104 unrelated Zang subjects. The frequency of CYP2C19(m1) allele was 0.308, which was in agreement with that in other published data.
%K cytochrome P450 2C19
%K genotype
%K Zang population
%K polymerase chain reaction
%K restricted fragment length polymorphism(RFLP)<br>细胞色素P450
%K 2C19
%K 基因型
%K 藏族
%K 聚合酶链反应
%K 限制性内切核酸酶片段长度多态(RFLP)
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=37B403CC7DB705B8&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=0B39A22176CE99FB&sid=70AC2EF7F2065E09&eid=E2546871E5B846EF&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=10