%0 Journal Article
%T Studies on the Genetic Diathesis of Asthma Bronchial<br>支气管哮喘遗传因子研究
%A ZHANG Ying-Qi~
%A SUN Bai-Yun~
%A DAI Jian-Jun~
%A WU Shou-Shan~
%A ZHANG An-Ping~
%A ZHAO Chen-Fu~
%A NING Shu-Cheng~
%A <br>张瑛琪
%A 孙白云
%A 戴建军
%A 武守山
%A 张岸平
%A 赵沉浮
%A 宁树成
%J 遗传
%D 2004
%I 
%X To study the association of genes polymorphisms in glutathione S-transferase M1 and T1 with asthma bronchial. The distribute frequency of allele(+) and allele(o) between GSTM1 and GSTT1 of 60 patients asthma bronchial and 60 control groups in Tangshan was studied with PCR. The result shown GSTM1 deficiency allele(0/0) frequency of asthma bronchial was 81.2%, which showed significantly higher(chi(2)=32.46, P<0.001; wchi(2)=28.75,P<0.001) than the control groups; GSTT1 was similar to GSTM1. But GSTT1 zero allele(0/0) frequency of asthma bronchial were 71.7%, which were significantly higher (chi(2)=26.72, P<0.001; wchi(2)=35.75, P<0.001) than the control groups(11.7%). Zero allele of GSTM1 and GSTT1 were showed the most features in the asthma bronchial. Associated significantly in the genes polymorphisms of GSTM1 and GSTT1 with asthma bronchial, their genes mutation may be the genetic risk factor of asthma bronchial.
%K glutathione S-transferase gene
%K genetic polymorphisms
%K asthma bronchial<br>谷胱甘肽-S-转移酶基因
%K 遗传多态性
%K 支气管哮喘
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=E5EA36BCD695F920&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=0B39A22176CE99FB&sid=2922B27A3177030F&eid=2DBBF45CC176713E&journal_id=0253-9772&journal_name=遗传&referenced_num=2&reference_num=9