%0 Journal Article
%T Tumor Necrosis Factor-a Gene Polymorphisms and Risk of Coronary Heart Disease<br>冠心病患者TNF-a 水平及其基因多态性的研究
%A XIANG Ping-Xia
%A LI Yan
%A ZHANG Ping-An
%A <br>向萍霞
%A 李艳
%A 张平安
%J 遗传
%D 2004
%I 
%X Tumor necrosis factor-alpha(TNF-alpha) is a cytokine that has multiple functions. It could be involved in cardiovascular pathophysiology. Given this possibility, we measured serum TNF-alpha level by ELISA and use PCR-RFLP methods to examine the distribution of TNF-alpha locus gene polymorphism at -857 and -863 sites in coronary heart disease(CHD) patients and matched controls. We found the serum level of TNF-alpha of CHD is higher than that of controls(P<0.05),-863 genotype and allele have significant difference between two groups(P<0.05),and there are no difference in two groups at -857 site.
%K 肿瘤坏死因子-α
%K 基因多态性
%K 冠心病
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=58EBCF0E27374E70&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=B31275AF3241DB2D&sid=4FBF7A066D63EF1A&eid=4A2C67480A6B9F95&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=18