%0 Journal Article
%T The I1307K Mutation and Protein Expression of APC Gene in Gastric Cancer<br>胃癌中APC基因I1307K突变及蛋白质表达 The I1307K Mutation and Protein Expression of APC Gene in Gastric Cancer
%A Xiu-Ju Sun
%A Zhi-Hong Zheng
%A Hao Fu
%A Hui-Mian Xu
%A Dong-Mei Hao
%A Yuan Yuan
%A Kai-Lai Sun
%A <br>孙秀菊
%A 郑志红
%A 付浩
%A 徐惠绵
%A 郝冬梅
%A 袁媛
%A 孙开来SUN Xiu-Ju
%A ZHENG Zhi-Hong
%A FU Hao
%A XU Hui-Mian
%A HAO Dong-Mei YUAN Yuan
%A SUN Kai-Lai
%J 遗传
%D 2003
%I 
%X In order to explore the correlation of the abnormalities of tumor suppressor gene APC with the carcinogenesis and progression of gastric cancer. The I1307K mutation of APC gene in gastric cancer was analysed using Amplification Refractory Mutation System PCR(ARMS ,PCR),also the expression of APC protein in gastric cancer of different stages was detected by immunohistochemical method. We found that there wasn't I1307K mutation of APC gene in 62 cases of blood samples of susceptible population in high incidence areas of gastric cancer and 45 cases of gastric cancer tissues. The positive rates of APC protein in gastric cancer (both early and progressive gastric cancer) were significantly lower than that in normal mucosa,the positive rates of APC protein in progressive gastric cancer were significantly lower than that in early gastric cancer,the positive rates of APC protein in gastric cancer with lymph node metastasis were significantly lower than that in gastric cancer without lymph node metastasis.So it was thought that there might be no correlation between the I1307K mutation of APC gene and carcinogenesis of gastric cancer in China,but the decreased expression of APC protein was closely related to the carcinogenesis,progression and lymph node metastasis of gastric cancer.
%K APC gene
%K I1307K mutation
%K protein
%K gastric cancer<br>胃癌
%K APC基因
%K I1307K
%K 突变
%K 蛋白质
%K 表达
%K 肿瘤抑制基因
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=CBB9F20A81CFC021&yid=D43C4A19B2EE3C0A&vid=C5154311167311FE&iid=38B194292C032A66&sid=82722E2B785EBF0D&eid=4290346F7268639E&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=15