%0 Journal Article
%T The Polymorphism of Nine STR Loci on the Genetic Original Identification of Complete Hydatidiform Mole<br>9个多态性STR基因座用于完全性葡萄胎的亲代来源鉴定 The Polymorphism of Nine STR Loci on the Genetic Original Identification of Complete Hydatidiform Mole
%A Ou Chun-Yi
%A Chen Meng-Hua
%A Niu Ming-Gang
%A <br>欧春怡
%A 陈孟华
%A 牛铭钢
%J 遗传
%D 2004
%I 
%X To explore the genetic origin of hydatidiform mole (CHM),33 cases of CHM were collected mainly from Harbin Red Cross Central hospital from 1998.6 to 2001.5 and studied by multiplex-PCR,products were separated using denaturing polyacrylamide gel and were detected by silver stain for 9 different STR loci analysis. Among 33 samples of CHM,DNA from only paternal origin was found in 27 cases (81.8%,27/33),and from both parents in 6 cases (18.2%,6/33); and in the former,the homozygous CHM and the heterozygous CHM were 22 cases (66.7%,22/33) and 5 cases (15.1%,5/33),respectively. There was difference between analysis of microsatellite DNA polymorphism and pathological diagnosis in hydatidiform moles' classification. The results suggest that the analysis of 9 polymorphic STR loci is suitable for genetic original identification of hydatidiform moles.
%K complete hydatidiform mole
%K polymorphic STR loci
%K molecular genetics
%K molecular pathology<br>完全性葡萄胎
%K 多态性STR基因座
%K 分子遗传学
%K 分子病理学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=1FDAFE6678EC4231&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=94C357A881DFC066&sid=D647AF4730396036&eid=FED67FBA0A707330&journal_id=0253-9772&journal_name=遗传&referenced_num=3&reference_num=17