%0 Journal Article
%T Studies of Genetic Polymorphisms of ADH2 and ALDH2 among the Han Population in Luoyang China<br>洛阳市汉族群体ADH2和ALDH2的基因多态性研究
%A ZHANG Zhu-mei
%A LIU Cha-zhen
%A BIAN Jian-chao
%A TANG Bo-ming JIANG Feng
%A WANG Qi-jun
%A WANG Qi-min
%A ZHU Xin
%A SHEN Fu-min
%A <br>张竹梅
%A 刘茶珍
%A 边建超
%A 汤伯明
%A 江峰
%A 王其军
%A 王启敏
%A 朱鑫
%A 沈福民
%J 遗传
%D 2002
%I 
%X In order to investigate genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang City, portions of exon 3 of ADH2 and exon 12 of ALDH gene were amplified by using polymerase chain reaction. The amplified products were electrophoresed on 10% undenatured vertical polyacrylamide gels and stained with argentine. Frequencies of ADH2 * 1 and ADH2 * 2 alleles are 42. 86% and 57. 14%. Frequencies of three genotypes of ADH2 are 22. 86% ,40. 00% and 37. 14% .respectively. Frequencies of ALDH2 * 1 and ALDH2 * 2 alleles are 85.24% and 14. 76%. Genotype frequencies of ALDH2 loci are 71. 43% N27. 62% and 0. 95% respectively. Genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang City are different from those among Taiwanese and Shanghainese. Frequency of ALDH2 * 1 / * 1 in Luoyang people is higher than those in Shanghai and Taiwan. Therefore, there is a higher resistance to alcohol drinking in the Han population in Luoyang.
%K polymerase chain reaction-amplified products length polymorphism
%K alcohol dehydrogenase 2
%K aldehyde dehydrogenase 2
%K genetic<br>洛阳市
%K 汉族群体
%K ADH2
%K ALDH2
%K 基因多态性
%K 乙醇脱氢酶2
%K 乙醛脱氢酶
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=99CFA43C16366235&yid=C3ACC247184A22C1&vid=B91E8C6D6FE990DB&iid=94C357A881DFC066&sid=640CCB6E396307A8&eid=323E8A365B085E0B&journal_id=0253-9772&journal_name=遗传&referenced_num=8&reference_num=14