%0 Journal Article
%T The role of epigenetic regulation in etiology of major depressive disorder<br>重性抑郁障碍发病的表观遗传调控假说
%A DANG Yong-Hui
%A LI Sheng-Bin
%A SUN Zhong-Sheng
%A <br>党永辉
%A 李生斌
%A 孙中生
%J 遗传
%D 2008
%I 
%X Epigenetics refers to the heritable, but reversible, regulation of various biological functions mediated principally through changes in DNA methylation and chromatin structure derived from histone modification. Recent research indicated that epigenetic mechanisms may play vital role in etiology of major psychosis, such as schizophrenia, bipolar disorder and drug addiction. With brief introduction of epigenetic molecular mechanisms and relevance of epigenetics to human common diseases, this review focuses on epigenetic hypothesis and some supporting evidence which are recently emerged in major depressive disorder (MDD).
%K 抑郁症
%K 表观遗传学
%K DNA甲基化
%K 组蛋白修饰
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=2F9C3670F4144CD90642ACCD60F61CFD&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=B31275AF3241DB2D&sid=D559883475316B44&eid=2B6C525BCE31A7DA&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=40