%0 Journal Article
%T Study on the Relationship between Sulfonylurea Receptor 1 Gene Polymorphism and Type 2 Diabetes Mellitus<br>磺酰脲类受体基因多态性与2型糖尿病的相关性研究 Study on the Relationship between Sulfonylurea Receptor 1 Gene Polymorphism and Type 2 Diabetes Mellitus
%A WANG Jin-Song~
%A ZHOU Ling~
%A CHENG Jin-Luo~
%A SHEN Mo-Yu~
%A <br>王劲松
%A 周玲
%A 成金罗
%A 沈默宇WANG Jin-Song
%A ZHOU Ling
%A CHENG Jin-Luo
%A SHEN Mo-Yu
%J 遗传
%D 2004
%I 
%X To study whether the 3c/t polymorphism of the sulfonylurea receptor 1 (SUR1) gene exon16 increased the risk of type 2 diabetes mellitus in type 2 diabetes mellitus pedigrees in Han population in south area of China. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used in 46 type 2 diabetes mellitus pedigrees. The polymorphism in SUR1 was tested and analyzed by Mantel-Haenszel chi(2) test. Frequencies of SUR1-3c/t polymorphism had no significant difference between type 2 diabetes mellitus and normal relatives (genotypes chi(2)=3.224, P=0.199; frequency of allele chi(2)=1.250, P=0.264). In all subjects, type 2 diabetes mellitus and normal relatives, SUR1-3c/t genotypes were listed (cc: 29.3%, 30.2%, 28.3%; ct: 50.7%, 53.8%, 47.2%; tt: 20%, 16.0%, 24.5% respectively). The frequencies of c were 54.7%, 57.1% and 51.9% respectively. The frequency of c is lower than Han population in northern China. The results show that SUR1 exon16-3c/t polymorphism is not associated with type 2 diabetes mellitus in the population.
%K non-insulin-dependent diabetes mellitus
%K sulfonylurea receptor 1
%K gene polymorphism<br>2型糖尿病
%K 磺酰脲类受体1
%K 基因多态性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=B0BD5C157A6C9C52&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=CA4FD0336C81A37A&sid=5D311CA918CA9A03&eid=59906B3B2830C2C5&journal_id=0253-9772&journal_name=遗传&referenced_num=9&reference_num=11