%0 Journal Article
%T Association Study of Five Pedigree with High Incidence of Schizophrenia<br>5个精神分裂症高发家系与COMT关联的分析 Association Study of Five Pedigree with High Incidence of Schizophrenia
%A Huai-An Wu
%A Xiao-Min Deng
%A Xiao-Hua Yan
%A Tie-Bang Liu
%A Ji-Ze Hu
%A Huan Gao
%A Qi-Jie Shen
%A <br>吴怀安
%A 邓小敏
%A 阎小华
%A 刘铁榜
%A 胡纪泽
%A 高欢
%A 沈其杰
%J 遗传
%D 2003
%I 
%X This study is to explore the relationship between polymorphism of Catechol O-methyltransferase gene and schizophrenia.Search for a gene predisposing to schizophrenia in the Han nationality in China.Five pedigrees with high incidence of schizophrenia were studied by polymerize chain reaction(PCR) and restriction fragment length polymorphism(RFLP) technique.Statistics analysis of the transmission/disequilibrium test (TDT) showed that the COMT gene is associatted with schizophrenia in the five pedigree with high incidence schizophrenia( P =0.0455).The results suggest that there might have a schizophrenia liability gene on 22 chromosome (22q11.2) in our studied pedigrees.
%K schizophrenia (SP)
%K association
%K Catechol O-methyltransferase(COMT)
%K gene
%K polymorphism<br>精神分裂症
%K 关联
%K 儿茶酚氧位甲基转移酶
%K 基因
%K 多态性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=C66B5D31EF613B97&yid=D43C4A19B2EE3C0A&vid=C5154311167311FE&iid=B31275AF3241DB2D&sid=4A8412AEEC89236B&eid=BBA8B1249CDAA6CE&journal_id=0253-9772&journal_name=遗传&referenced_num=7&reference_num=11